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Sodium salicylate is a sodium salt. It can be prepared from sodium phenolate and carbon dioxide under higher temperature and pressure.
Sodium salicylate is of the salicylate family and this compound is known to trigger Reye's Syndrome in children and adults, usually following a viral infection such as influenza or chicken pox. Products containing such salicylates should not be given to children under the age of 19.
It is used in medicine as an analgesic and antipyretic. Sodium salicylate also acts as non-steroidal anti-inflammatory drug (NSAID), and induces apoptosis in cancer cells and also necrosis. It may also be used as a phosphor for the detection of vacuum ultraviolet radiation and electrons.
Side Effects And Special Precautions:Sodium Salicylate is a gastric irritant and sodium bicarbonate is often given with it to reduce this effect (however the bicarbonate also increases rate of excretion and this lowers the concentration of salicylate in the blood). Some persons, especially asthmatics, exhibit notable sensitive which may provoke various reactions including urticaria, angioneurotic oedema, rhinitis and severe, even fatal, paroxysmal bronchospasm and dyspnoea.
The haemorrhagic effects on gastric mucosa may be enhanced by anticoagulants. The activity of methotrexate may be markedly enhanced and its toxicity, increased. and other may mask the respiratory symptoms of overdosage and have been reported to enhance its toxicity.